Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes

Table 2

Treatment and control peptides for in vitro and in vivo studies. The following table contains information on the sequences, MHC promiscuity, and parental protein location of the peptides and controls used in these studies.

Peptide name	Amino acids	Sequence	HLA motifs	EpiMatrix cluster score	Location in IgG
hTregitope IgG-167	26	PAVLQSSGLYSLSSVVTVPSSSLGTQ	20	30.05	CH1
hTregitope IgG-289	21	EEQYNSTYRVVSVLTVLHQDW	14	22.57	CH2
mTregitope IgG-167	20	PAVLQSDLYTLSSSVTVPSS	n/a	n/a	CH1
mTregitope IgG-289	18	EEQFNSTFRSVSELPIMHQ	n/a	n/a	CH2
mPPI 7–23	17	FLPLLALLALWEPKPTQ	11	18.69	—
mPPI 20–35	16	KPTQAFVKQHLCGPHL	2	−2.82	—
mPPI 33–47	15	PHLVEALYLVCGERG	3	−0.69	—
mPPI 71–86	16	SPGDLQTLALEVARQK	0	−6.59	—
mPPI 77–92	16	TLALEVARQKRGIVDQ	2	−3.1	—
TetTox 830–844	15	QYIKANSKFIGITEL	13	25.65	—
Flu-HA 308–318	13	PRYVKQNTLKLAT	10	21.82	—
OVA 323–339	17	KISQAVHAAHAEINEAG	4	−0.39	—