The Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina
Figure 4
Diabetes does not alter retinal iNOS expression in the mouse lacking MMP-9. Gene expression of iNOS was quantified in the retina of wild-type (WT) mice and MMP-9 KO (KO) mice diabetic for 3 months by real-time quantitative PCR. The mRNA levels of the targeted proteins were adjusted to the levels of β-actin in each sample. Results are expressed as mean ± s.d. of at least five to six mice in each group. compared with WT nondiabetic mice and compared to WT diabetic mice. WT and WD = wild-type nondiabetic and diabetic, respectively, and KD = MMP-9 KO diabetic mice.
