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Journal of Diabetes Research
Volume 2013, Article ID 737485, 10 pages
Research Article

The Missing Heritability in T1D and Potential New Targets for Prevention

1Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
2Department of Microbiology and Immunology, Center for Immunogenetics and Inflammatory Diseases, Drexel University College of Medicine, Philadelphia, PA 19129, USA
3Children’s Hospital Oakland Research Institute, Oakland, CA 94609, USA
4Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA

Received 7 January 2013; Accepted 13 February 2013

Academic Editor: Norihide Yokoi

Copyright © 2013 Brian G. Pierce et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplemental Figure shows the position of the D105N polymorphism (discussed in Figure 3 of the main text) in the crystal structure of the CF34 TCR (which is encoded by the TRBV 11-2*01 allele) in complex with HLA-B*0801 and a viral peptide (Protein Data Bank ID 3FFC). The position in question (which is residue 98 using IMGT numbering and in the PDB entry) is shown in red and forms a salt bridge with a positive residue (Arg75; shown as cyan sticks) in the Vβ domain but it is away from the pMHC (approximately 22 Å) and CDRs. TCR α chain is light blue, β chain is blue, peptide is magenta, and MHC is green. The supplemental figure was generated using PyMOL (

  1. Supplementary Figure