The Novel Oral Drug Subetta Exerts an Antidiabetic Effect in the Diabetic Goto-Kakizaki Rat: Comparison with Rosiglitazone

Figure 1

Glucose tolerance to glucose (2 g/kg per os) in adult diabetic male GK/Par rats before (d0), after acute treatment (d1), and after chronic treatment (d28) with RAD of Abs to β-InsR, RAD of Abs to eNOS, Subetta, H₂O (distilled water), Rosiglitazone (Rosi), or carboxy-methyl-cellulose (CMC). On d1 and d28, drugs or vehicle were administrated at 9.00. OGTT were performed at 12.00 in nonanaesthetized rats fasted from 9.00 (postabsorptive state). Glucose responses during the glucose tolerance test were calculated as incremental plasma glucose values integrated over the 120 min period following the glucose injection (AUC glucose; g/L/120 min). Each point represents the mean ± S.E.M. of 12 observations/group. ^∗∗∗𝑃<0.001 versus the related d0-value within each group. ^∗∗𝑃<0.01 versus the related d0-value within each group. ^∗𝑃<0.05 versus the related d0-value within each group.