The Novel Oral Drug Subetta Exerts an Antidiabetic Effect in the Diabetic Goto-Kakizaki Rat: Comparison with Rosiglitazone

Table 1

Effect of test articles and appropriate controls on Goto Kakizaki/Par male rats basal (non-fed state) plasma glucose level (mg/dL; M ± SEM) during treatment period (28 days) (𝑛=12 in each group).

Groups	Plasma glucose level (mg/dL)
	Day 1 (d1)	Day 4 (d4)	Day 8 (d8)	Day 12 (d12)	Day 16 (d16)	Day 20 (d20)	Day 24 (d24)	Day 28 (d28)
RAD of Abs to β-InsR	168±8	167±8	166±8	165±7	164±6	153±5^∗∗	156±4^∗	153±4^∗∗
RAD of Abs to eNOS	163±10	159±9	159±8	179±9^∗	169±10	159±10	167±9	167±11
Subetta	167±3	165±4	158±5	163±5	160±7	152±5^∗	158±5	147±4^∗∗∗##
Rosi	169±3^##	154±5	156±5	153±4	148±3	150±4	151±5	145±4
H2O	176±6	176±10	174±12	169±10	157±6^∗	162±10	165±5^∗	165±4^∗
CMC	186±9	172±8	167±13	157±8^∗∗	148±5^∗∗	144±4^∗∗	155±4^∗∗∗	149±5^∗∗

^∗𝑃<0.05 (versus d1)
^∗∗𝑃<0.01 (versus d1)
^∗∗∗𝑃<0.001 (versus d1)
^##𝑃<0.01 (versus control (H₂O or CMC, resp.)).