The Novel Oral Drug Subetta Exerts an Antidiabetic Effect in the Diabetic Goto-Kakizaki Rat: Comparison with Rosiglitazone

Table 3

Basal (non-fed sate) plasma adiponectin (ng/mL; M ± SEM), leptin (ng/mL; M ± SEM), and glucagon (ng/mL; M ± SEM) in Goto Kakizaki/Par male rats (𝑛=12 in each group).

Groups	Plasma adiponectin level (ng/mL)		Plasma leptin level (ng/mL)		Plasma glucagon level (ng/mL)
	Day 1 (d1)	Day 28 (d28)	Day 1 (d1)	Day 28 (d28)	Day 1 (d1)	Day 28 (d28)
RAD of Abs to β-InsR	9539.2±529.2	9751.4±273.5	1669.2±142.9	1664.1±106.5	196.5±25.0	230.3±21.4
RAD of Abs to eNOS	10362.6±433.9	10773.3±612.5	1437.9±86.5	1673.7±106.2^∗∗##	242.1±29.0	184.2±19.2
Subetta	10635.9±416.5	11133.9±567.4	1924.9±328.4	1869.8±236.4	233.0±24.3	165.3±25.5
Rosi	13816.2±507.1^###	14486.9±436.4^###	1293.0±85.3^##	1334.1±61.6	152.0±11.9	211.4±28.7
H2O	10197.3±392.9	9797.8±482.0	2266.1±210.1	2125.6±254.5	199.9±20.0	202.9±21.0
CMC	9686.2±415.5	9496.3±356.0	2354.0±413.9	2034.7±307.0	205.4±29.6	232.8±49.3

^∗∗𝑃<0.01 (versus d1)
^##𝑃 < 0.01 (versus control (H₂O or CMC, resp.))
^###𝑃 < 0.001 (versus control (H₂O or CMC, resp.)).