Journal of Diabetes Research / 2013 / Article / Tab 1 / Review Article
Animal Models of GWAS-Identified Type 2 Diabetes Genes Table 1 Summary of the major phenotype of the different colonies of ZnT8 KO mice. ZnT8-α KO and ZnT8-β KO for α and β -cell-specific knockout mice, respectively; GSIS for glucose-stimulated insulin secretion.
Phenotype/model ZnT8KO-London 97 ] ZnT8KO-98 ] ZnT8KO-99 ] ZnT8KO-100 ] Brd × C57BL/6J) ZnT8KO-Vanderbilt [101 ] (C57BL/6J) ZnT8-α KO ZnT8-β KO 102 ] Glucose tolerance ≤6 weeks ♂ intolerant ♂ intolerant Normal ♂ intolerant Normal Intolerant 12 weeks ♂ intolerant ♂ normal Normal ≥18 weeks Normal Normal Normal Insulin sensitivity Normal Normal Normal Normal Normal Plasma glucose ♂: Elevated (fasting) at 6 wks, normal afterwards. Normal Normal Normal (fasting) Plasma insulin Decreased Normal Decreased Normal (fasting) Normal. Normal Islet insulin content Normal Normal Normal Insulin secretion In vivo Reduced In vitro Basal secretion enhanced GSIS enhanced GSIS normal GSIS reduced GSIS normal Reduced first phase Glucagon secretion Unaffected Insulin processing Normal Normal Granule morphology Abnormal Abnormal Abnormal Normal Normal Abnormal
