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Journal of Diabetes Research
Volume 2013 (2013), Article ID 967097, 8 pages
http://dx.doi.org/10.1155/2013/967097
Clinical Study

The Impact of Hyperglycemic Emergencies on the Kidney and Liver

1Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People’s Hospital, Huai'an 223002, China
2Department of Endocrinology and Metabolism, The Third Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330008, China
3Department of Critical Care Medicine, The Affiliated Yixing People’s Hospital of Jiangsu University, No. 75 Tong Zhenguan Road, Yixing, Jiangsu 214200, China
4Department of Emergency, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People’s Hospital, Huai'an 223002, China
5Department of Clinical Laboratory, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People’s Hospital, Huai'an, Jiangsu 223002, China

Received 18 July 2013; Revised 4 September 2013; Accepted 19 September 2013

Academic Editor: Giuseppe Paolisso

Copyright © 2013 Feng Bai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Studies on the alterations of liver and kidney function parameters in patients with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) were limited. Participants with DKA, DK, non-DK, and healthy controls were enrolled in the current study. Parameters of liver and kidney function were measured and evaluated. The patients with DKA had higher levels of plasma glucose, hemoglobin A1c (HbA1c), uric acid, and creatinine but lower levels of transferases and protein compared with the other three groups ( for all). The patients with DK had higher levels of plasma glucose and HbA1c but lower levels of glutamyl transpeptidase and protein compared with the non-DK and control groups ( ). Prealbumin levels were significantly reduced in the severe DKA patients compared with the mild/moderate DKA patients. Serum prealbumin levels were correlated with albumin levels ( , ), HCO3 ( , ), and arterial pH ( , ) in the DKA patients. A diagnostic analysis showed that lower prealbumin levels significantly reflected the presence of hyperglycemic emergencies ( ). Liver and kidney function parameters deteriorated, especially in DKA. Prealbumin levels can be of value in detecting the presence of hyperglycemic crisis. This clinical trial is registered with ChiCTR-OCH-12003077.