Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells

Table 1

Highly ranked genes in T2DM-control study.

(a) Highly ranked genes with high percentages in T2DM-control study

Gene symbol	Official full name	Location	Percentage	References
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	Chr8; 56,792,386-56,925,006 (+): 8q13	61.1%	Müller et al., 2000 [14]
DENND1B	DENN domain-containing protein 1B	Chr1; 197,473,878-197,744,623 (−): 1q31.3	50%
MRPL30	Mitochondrial ribosomal protein L30	Chr2; 99,797,542-99,816,020 (+): 2q11.2	50%
POC1B	POC1 centriolar protein homolog B (Chlamydomonas)	Chr12; 89,813,495-89,920,039 (−): 12q21.33	50%
PRKCB	Protein kinase C betatype PKC-beta (PKC-B)	Chr16; 23,847,300-24,231,932 (+): 16p11.2	50%	Zhang et al., 2004 [22]
RP4-655J12.3		Chr1; 116,916,755-116,917,283 (−): N/A	50%

(b) Highly ranked genes nearby SNPs conferring susceptibility to T2DM

Gene symbol	Official full name	Location	Percentage	References	SNPs; (Chr pos; frequencies)
HIBADH	3-Hydroxyisobutyrate dehydrogenase	Chr7; 27,565,059-27,702,620 (−): 7p15.2	42.9%	Deng et al., 2010 [15]	rs864745; (28,180,556; T = 0.65, C = 0.35); rs849134; (28,196,222; A = 0.65, G = 0.35)
TMBIM4	Transmembrane BAX inhibitor motif containing 4	Chr12; 66,530,717-66,563,807 (−): 12q14.1-q15	42.9%		rs1531343; (66,174,894; G = 0.81, C = 0.19)

Note: Chr pos: chromosome position; frequencies: the allele frequencies in 1000 genomes (http://www.ncbi.nlm.nih.gov/variation/tools/1000genomes/).