The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

Figure 3

Oral glucose tolerance test (OGTT) in SDT rats. Changes in plasma glucose and insulin concentrations during OGTT (2 g/kg). At 14 and 18 weeks, SDT rats were nondiabetic but the marked elevation of plasma glucose and lower insulin concentration were observed after glucose loading. At 24 weeks, SDT rats were diabetic and showed further elevation of plasma glucose level because of diminished insulin secretion. White square: male SD rats, green square: male SDT rats. Data represent means ± SD (𝑁=6). ^∗𝑃<0.05, ^∗∗𝑃<0.01 (versus SD rats, unpaired t-test). Figures are modified from [8].

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