Figure 4: Histopathological observations in pancreas (islet) of SDT rats. Histopathological changes in the pancreatic islets of the male SDT rats. Congestion or microcapillary extension (a) and hemorrhage (b) in the pancreatic islets were observed (HE stain). Replacement of islet cells by connective tissues with advanced fibrosis (c, d) (MT stain). Immunohistochemistry of islet shows almost all of the β-cells (brown, insulin immunoreactive) disappeared from the islets, whereas α-cells (pink, glucagon immunoreactive) were still observed at 38 weeks (e, f). Bar 100 μm. Figures are modified from [8].