Figure 6: Histopathological observations in kidney of SDT rats. Histological and immunohistological analysis of glomeruli in SD rats (a–c) and SDT rats (d–f). In the glomeruli of SDT rats, basement membrane thickening and mesangial matrix proliferation were observed at 50 weeks of age (bar 20 μm). Nodular lesions were found in a few glomeruli from 68-week-old SDT rats (g) (PAS stain, bar 20 μm). In the renal tubules of SDT rats, dilation (arrowhead) and glycogen deposition in the epithelium (*) were observed (h) (HE stain, bar 50 μm). Figures are modified from [41].