Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions
Figure 4
The mRNA levels of FN in each group of GMCs. (a) RT-PCR strip chart for different times. The mRNA expression of all Notch signaling components were significantly upregulated at the 12 h time point. The expression of Notch1 mRNA was enhanced significantly at the 12 h time point. The expression levels of Hes1 mRNA were upregulated significantly at the 12 h and 24 h time points, with the 12 h increase being more obvious. (b) The corresponding relative gray value statistics graph of the mRNA level. ▴ versus NC group; • versus 12 h group; ▪ versus 24 h group.
