T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease
Table 6
Selected comparisons of the polymorphic variants distribution of tested genes between type 2 DM nephropathy patients, chronic infective tubulointerstitial nephritic patients, and healthy subjects.
Genotype
Genotype frequencies
Odds ratio (95% CI)
Two-tailed
Type 2 DM nephropathy versus chronic infective tubulointerstitial nephritis
IL18 rs360719
= 248
= 77
TT
133 (0.54)
54 (0.70)
Referent
0.033
CT
102 (0.41)
19 (0.25)
2.180 (1.217–3.905)
CC
13 (0.05)
4 (0.05)
1.320 (0.412–4.228)
0.783
CT + CC
115 (0.46)
23 (0.30)
2.030 (1.173–3.512)
MAF
128 (0.26)
27 (0.18)
1.636 (1.031–2.596)
0.046
Chronic infective tubulointerstitial nephritis versus healthy controls
IL18 rs360719
= 77
= 240
TT
54 (0.70)
121 (0.50)
Referent
0.005
CT
19 (0.25)
98 (0.41)
0.434 (0.242–0.781)
CC
4 (0.05)
21 (0.09)
0.427 (0.140–1.303)
0.160
CT + CC
23 (0.30)
119 (0.50)
0.433 (0.250–0.750)
MAF
27 (0.18)
140 (0.29)
0.516 (0.326–0.818)
0.006
DM: diabetes mellitus; MAF: minor allele frequency. Significant differences are indicated using bold font.
aSignificant after the Bonferroni correction ().
