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Journal of Diabetes Research
Volume 2014, Article ID 128014, 5 pages
http://dx.doi.org/10.1155/2014/128014
Research Article

Decreased Plasma Nesfatin-1 Level Is Related to the Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus

1Department of Endocrinology, Central People’s Hospital of Tengzhou City, Tengzhou, Shandong 277500, China
2Department of Medicine, Maternal and Child Care Service Centre of Tengzhou City, Tengzhou, Shandong 277500, China
3Department of Endocrinology, Qianfoshan Hospital of Shandong University, Jinan, Shandong 250000, China

Received 27 March 2014; Accepted 21 May 2014; Published 4 June 2014

Academic Editor: Hiroshi Okamoto

Copyright © 2014 Fupeng Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. Methods. 55 euthyroid patients were enrolled in this study including 30 patients with T2DM and 25 patients with impaired glucose regulation (IGR). 30 age-matched healthy people were also included as the control. The plasma levels of nesfatin-1, thyrotropin (TSH), and glycosylated hemoglobin (HbA1c) as well as the body mass index (BMI) were comparatively analyzed among the three groups. Results. The nesfatin-1 was significantly lower in patients with T2DM than in patients with IGR and in the control. On the contrary, the TSH level was significantly higher in patients with T2DM than in patients with IGR and in the control. Simple regression analysis showed that the plasma nesfatin-1 was negatively correlated with the TSH and HbA1c levels and positively correlated with the BMI. With multiple stepwise regression analysis, the nesfatin-1 remained to be independently correlated with the TSH, BMI, and HbA1c. Conclusions. The study was suggesting a role of nesfatin-1 in thyroid dysfunction in patients with T2DM.