Decreased Plasma Nesfatin-1 Level Is Related to the Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus

Table 1

Clinical characteristics of the patients (𝑥±𝑠).

Group	T2DM	IGR	NGT
Age (year)	61.23 ± 8.83	59.04 ± 9.01	59.60 ± 9.26
Number (M/F)	30 (16/14)	25 (13/12)	30 (14/16)
Body mass index	26.11 ± 2.55*	26.12 ± 2.07*	24.72 ± 2.48
Duration of diabetes (year)	9.03 ± 3.48	—	—
Fasting blood glucose (mmol/L)	7.37 ± 1.15^**▲	5.75 ± 0.54**	5.00 ± 0.46
Fasting insulin (mIU/L)	7.72 ± 0.86**	7.83 ± 3.73**	5.56 ± 1.27
HOMA-IR	2.54 ± 0.55^**▲	1.99 ± 0.92**	1.24 ± 0.33
HbA1c (%)	7.23 ± 1.27^**▲	5.64 ± 0.42	5.63 ± 0.61
Triglycerides (mmol/L)	2.78 ± 1.71^**△	1.79 ± 1.24	1.57 ± 1.09
Total cholesterol (mmol/L)	5.56 ± 1.14	5.56 ± 1.09	5.22 ± 0.99
High density lipoprotein cholesterol (mmol/L)	1.43 ± 0.29	1.43 ± 0.26	1.35 ± 0.37
Low density lipoprotein cholesterol (mmol/L)	3.21 ± 0.90^△	3.78 ± 0.78*	3.08 ± 1.28
Free triiodothyronine (pmol/L)	4.72 ± 0.63	5.04 ± 1.05	5.07 ± 0.74
Free thyroxine (pmol/L)	16.87 ± 2.45	16.85 ± 2.35	17.21 ± 1.58
Thyrotropin (uIU/mL)	2.10 ± 1.09^**△	1.50 ± 0.73	1.46 ± 0.60
Thyroid peroxidase antibody (pmol/L)	1.93 ± 1.67	1.65 ± 1.71	1.59 ± 1.67
Thyroglobulin antibody (pmol/L)	1.64 ± 0.78	1.50 ± 1.12	1.81 ± 2.44

Data are expressed as mean ± SD. T2DM: type 2 diabetes mellitus; IGR: impaired glucose regulation; NGT: normal glucose tolerance; HOMA-IR: HOMA-insulin resistance index; HbA1c: glycosylated hemoglobin; * < 0.05, ** < 0.01 versus NGT group; △ < 0.05, ▲ < 0.01 versus IGR group.