Chronic Treatment with Ang-(1-7) Reverses Abnormal Reactivity in the Corpus Cavernosum and Normalizes Diabetes-Induced Changes in the Protein Levels of ACE, ACE2, ROCK1, ROCK2 and Omega-Hydroxylase in a Rat Model of Type 1 Diabetes
Figure 6
The level of omega-hydroxylase protein expression in the corpus cavernosum of nondiabetic (C), diabetic (STZ), and STZ-rats chronically treated either with Ang-(1-7) alone (STZ + Ang-(1-7)) or in combination with A779 (STZ + Ang-(1-7) + A779). Panel (a) is a representative western blot showing the level of omega()-hydroxylase protein and -actin as a loading control. Panels (b) and (C) are densitometry histograms showing levels of omega()-hydroxylase protein normalized to actin. ; . Asterisk (*) indicates significantly different () mean values from normal nondiabetic rats (C), whereas hash (#) indicates significantly different mean values () from diabetic rats (STZ).
