The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate

Figure 1

MS-275 alleviates apoptosis caused by palmitate in isolated human islets and MIN6 cells. Effect of MS-275 on (a) the number of pyknotic nuclei and (b) histone-associated DNA fragments. MIN6 or dispersed human islets cells were cultured with 0.5 mM palmitate (Palm, Sigma Aldrich, St. Louis, MO) or bovine serum albumin (BSA; −) with 1 μM MS-275 (Sigma Aldrich, St. Louis, MO) or vehicle (DMSO; −) for 48 hrs. The data are the mean ± SD of 4 independent experiments ().

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