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Journal of Diabetes Research
Volume 2014, Article ID 195739, 7 pages
Research Article

The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate

1European Genomic Institute for Diabetes (EGID) FR 3508, University of Lille, CNRS UMR 8199, and Faculty of Medicine West, 1 Place de Verdun, 59045 Lille, France
2Department of Endocrine Surgery, Lille University Hospital, INSERM UMR 859, University of Lille, EGID FR 3508, Biotherapies for Diabetes, Lille, France

Received 28 August 2014; Revised 26 November 2014; Accepted 7 December 2014; Published 31 December 2014

Academic Editor: Kazuya Yamagata

Copyright © 2014 Valérie Plaisance et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Effect of palmitate on the HDACs activity and expression.

Supplementary Figure 2: Measurement of preproinsulin mRNA, insulin content and glucose-induced insulin secretion in response to MS-275.

  1. Supplementary Material