Data Mining for Identifying Novel Associations and Temporal Relationships with Charcot Foot

Table 2

Novel or poorly known associations with Charcot foot based on 388 patients with Charcot foot. All disorders listed in this table temporally preceded Charcot foot in a statistically significant (𝑃<0.001) number of patients.

Disease category	ICD-9 code	ICD-9 description	Number (%) with both disorders	Association odds ratio	Association 𝑃 value	Temporal 𝑃 value
Endocrine, nutritional and metabolic diseases, and immunity disorders	244.9	Hypothyroidism	42 (10.8)	6.1	3.2×10^−35	9.4×10^−4
	272.0	Hypercholesterolemia	82 (21.1)	17.9	7.0×10^−223	3.2×10^−5
	272.4	Hyperlipidemia	173 (44.6)	17.4	6.4×10^−321	1.1×10^−12
	276.3	Alkalosis	13 (3.4)	14.0	4.1×10^−32	2.4×10^−4
	276.5	Volume depletion disorder	84 (21.6)	8.1	3.0×10^−90	5.0×10^−15
Sense organs	366.16	Senile nuclear cataract	110 (28.4)	13.3	3.2×10^−195	7.7×10^−4
Circulatory system	401.1	Benign essential hypertension	113 (29.1)	13.3	3.3×10^−197	1.2×10^−5
	402.10	Benign hypertensive disease without heart failure	15 (3.9)	6.6	1.9×10^−15	9.8×10^−4
	411.1	Intermediate coronary syndrome	38 (9.8)	13.9	1.2×10^−88	1.2×10^−4
	413.9	Angina pectoris	41 (10.6)	13.1	8.2×10^−89	1.1×10^−4
	414.0	Coronary atherosclerosis	18 (4.6)	7.2	2.2×10^−20	7.6×10^−6
	414.00	Coronary atherosclerosis, vessel type	155 (39.9)	18.6	<5 ×  10^−324	4.5×10^−10
	414.01	Coronary atherosclerosis, native artery	97 (25.0)	16.3	2.2×10^−226	8.1×10^−6
	414.02	Coronary atherosclerosis, autologous graft	11 (2.8)	15.7	1.1×10^−30	9.8×10^−4
	414.9	Chronic ischemic heart disease	49 (12.6)	14.7	2.5×10^−118	6.2×10^−7
	424.0	Mitral valve disorder	32 (8.2)	7.4	8.4×10^−36	1.1×10^−4
	425.4	Cardiomyopathy, primary	44 (11.3)	11.6	2.7×10^−82	2.5×10^−5
	427.9	Cardiac dysrhythmia	168 (43.3)	7.6	1.5×10^−119	1.7×10^−31
	428.0	Congestive heart failure	84 (21.6)	11.0	1.5×10^−129	2.4×10^−6
	428.9	Heart failure, not otherwise specified	38 (9.8)	10.1	5.6×10^−61	4.7×10^−4
	429.9	Heart disease, not otherwise specified	39 (10.1)	10.5	9.3×10^−66	3.4×10^−7
	440.21	Atherosclerosis of native arteries of the extremities with intermittent claudication	93 (24.0)	48.5	<5 ×  10^−324	5.3×10^−5
	443.9	Peripheral vascular disease	95 (24.5)	38.5	<5 ×  10^−324	1.9×10^−4
Respiratory system	465.9	Acute upper respiratory infection	93 (24.0)	2.7	2.0×10^−17	1.9×10^−11
	466.0	Acute bronchitis	75 (19.3)	5.5	4.7×10^−49	2.2×10^−6
	473.9	Chronic sinusitis	35 (9.0)	4.4	4.3×10^−19	1.2×10^−4
	477.9	Allergic rhinitis	40 (10.3)	2.3	8.5×10^−07	1.8×10^−4
	493.90	Asthma (without status asthmaticus)	46 (11.9)	3.0	2.2×10^−13	1.8×10^−6
	518.3	Pulmonary eosinophilia	125 (32.2)	7.1	1.1×10^−97	1.8×10^−22
Digestive system	530.81	Esophageal reflux	64 (16.5)	4.7	2.2×10^−35	7.7×10^−5
	560.9	Intestinal obstruction, not otherwise specified	30 (7.7)	6.5	1.1×10^−28	3.2×10^−4
Genitourinary system	596.9	Bladder disorder, not otherwise specified	12 (3.1)	7.3	3.1×10^−14	4.9×10^−4
	607.84	Impotence, organic origin	33 (8.5)	14.0	2.1×10^−78	3.2×10^−4
Skin and subcutaneous tissue	692.9	Contact dermatitis	52 (13.4)	3.3	3.5×10^−17	3.6×10^−5
Musculoskeletal system and connective tissue	724.2	Lumbago	117 (30.2)	6.7	2.0×10^−86	8.9×10^−11
	729.1	Myalgia/myositis, not otherwise specified	55 (14.2)	9.1	2.9×10^−74	3.6×10^−4
	715.90	Osteoarthrosis, not otherwise specified	99 (25.5)	17.3	2.9×10^−245	1.1×10^−4
Injury and poisoning	860.0	Traumatic pneumothorax	27 (7.0)	6.7	6.2×10^−27	3.1×10^−4
	847.0	Sprain/strain of neck	21 (5.4)	5.7	1.5×10^−17	2.2×10^−4