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Journal of Diabetes Research
Volume 2014, Article ID 215473, 7 pages
Clinical Study

Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General Population

Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing’an District, Shanghai 200040, China

Received 7 November 2013; Revised 11 January 2014; Accepted 20 January 2014; Published 18 March 2014

Academic Editor: Mark A. Yorek

Copyright © 2014 Zi-Hui Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The purpose of this study was to evaluate the predictive value of DM and resting HR on CAN in a large sample derived from a Chinese population. Materials and Methods. We conducted a large-scale, population-based, cross-sectional study to explore the relationships of CAN with DM and resting HR. A total of 387 subjects were diagnosed with CAN in our dataset. The associations of CAN with DM and resting HR were assessed by a multivariate logistic regression (MLR) analysis (using subjects without CAN as a reference group) after controlling for potential confounding factors. The area under the receiver-operating characteristic curve (AUC) was used to evaluate the predictive performance of resting HR and DM. Results. A tendency toward increased CAN prevalence with increasing resting HR was reported (P for trend ). MLR analysis showed that DM and resting HR were very significantly and independently associated with CAN ( for both). Resting HR alone or combined with DM (DM-HR) both strongly predicted CAN (AUC = 0.719, 95% CI 0.690–0.748 for resting HR and AUC = 0.738, 95% CI 0.710–0.766 for DM-HR). Conclusion. Our findings signify that resting HR and DM-HR have a high value in predicting CAN in the general population.