Ang (1–7) Protects Islet Endothelial Cells from Palmitate-Induced Apoptosis by AKT, eNOS, p38 MAPK, and JNK Pathways
Figure 2
Ang (1–7) blocked palmitate-induced apoptosis in MS-1 cells. Lipoapoptosis depends on the exposure time (a). DNA fragmentation (b) and flow cytometry (c) measured in MS-1 cells exposed to palmitate (0.25 mmol/L) for 24 h, alone or in combination with Ang (1–7) (10−6 mol/L) or A-779 (10−5 mol/L). (c)(A): CON group; (c)(B): PA group; (c)(C): PA + Ang (1–7) group; (c)(D): PA + Ang (1–7) + A779 group. Values are mean ± SEM, for each group. # versus CON; * versus PA; & versus PA + Ang (1–7).
