Ang (1–7) Protects Islet Endothelial Cells from Palmitate-Induced Apoptosis by AKT, eNOS, p38 MAPK, and JNK Pathways
Figure 5
Effect of JNK and P38 pathway on antilipoapoptosis effect of Ang (1–7). Cells were incubated in palmitate (0.25 mmol/L) for 24 h with or without Ang (1–7) (10−6 mol/L), A-779 (10−5 mol/L), the JNK inhibitor SP600125 (2 × 10−5 M) or the p38 MAPK inhibitor SB203580 (10−5 M). ROS production (a), JNK phosphorylation (b), P38 phosphorylation (c), and DNA fragmentation were measured (d, e). Values are mean ± SEM, for each group. # versus CON; * versus PA; & versus PA + Ang (1–7).
