BlockingαVβ3 Integrin Ligand Occupancy Inhibits the Progression of Albuminuria in Diabetic Rats

Figure 2

Urinary albumin and creatinine were measured in spot urine samples from all rats from each group () at 4 time points (at the start of study week 0 (a), 4 weeks after the induction of hyperglycemia (b); control, 8 weeks of diabetes + with 4 wks vehicle (diabetic) or C-loop antibody treatment (c); control, 12 weeks of diabetes with 8 wks vehicle (diabetic); or 8 weeks of C-loop antibody treatment (d)). The results are shown as μg albumin/mg creatine (mean ± SEM). when the vehicle-treated hyperglycemic animals (diabetic) were compared with controls (con) or the hyperglycemic animals treated with the C-loop antibody (diabetic + C-loop).

(a)

(b)

(c)

(d)