BlockingαVβ3 Integrin Ligand Occupancy Inhibits the Progression of Albuminuria in Diabetic Rats

Table 2

Analysis of fibrotic proteins in kidney lysates.

	Control	Fold increase between control and diabetic	Diabetic	Fold difference between diabetic and diabetic + C-loop	Diabetic + C-loop
TGF-β	7722 ± 1280	2.3	17564 ± 2122*	2.8	6242 ± 641.6^+
Collagen type IV	4892 ± 1457	3.7	18249 ± 1165*	2.3	7810 ± 1849^+
TS-1	6261 ± 1205	2.8	17735 ± 3795*	2.2	8032 ± 1051^+

Mean (±SEM) of arbitrary scanning units (obtained from analysis of western immunoblots) and fold difference between treatment groups. for each analysis is indicated in the table. * < 0.05 when levels in control nondiabetic animals are compared with diabetic animals that received vehicle and when the levels from those animals are compared with the levels obtained from diabetic rats treated with the C-loop antibody. ⁺: NS when diabetic + C-loop antibody treatment is compared to control animals.