The GLP-1 Analogue Exenatide Improves Hepatic and Muscle Insulin Sensitivity in Diabetic Rats: Tracer Studies in the Basal State and during Hyperinsulinemic-Euglycemic Clamp

Figure 6

Exogenous glucose infusion rates (GIR) and 2-deoxyglucose uptake into muscle. The GIR required to maintain the glucose levels at the clamp point (6-7 mmol/L) was higher () in the D + E group rats than that in the D group rats, while it was still significantly lower () than that in the C group rats. The GIR did not differ between the C group rats and in the C + E group rats (a). Exenatide treatment for 8 weeks markedly increased glucose uptake in diabetic rat gastrocnemius compared with the vehicle-treated diabetic rats (). Increased glucose uptake was also found in the C + E group rats compared with the C group rats, but this did not reach statistical significance (b). C: nondiabetic control; C + E: nondiabetic + exenatide; D: diabetic; D + E: diabetic + exenatide. Data are presented as mean ± SD. , compared with basal. , compared with C group. , compared with C + E group. ^§,   compared with D group.

(a)

(b)