Association between eNOS 4b/a Polymorphism and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Meta-Analysis

Table 3

Meta analysis of the association of eNOS-4b/a gene polymorphism with DR in type 2 diabetes.

Genetic model	Populations	Studies (𝑛)	Number of cases/controls	Heterogeneity; 𝑄 test 𝑃-value	𝐼^2 (%)	OR (95% CI)	𝑃 value
a versus b	All	15	3183/3410	0.0005	64	0.94 (0.79–1.11) (REM)	0.48
	Asian	10	2265/2564	0.006	61	0.90 (0.73–1.11) (REM)	0.32
	Caucasians	4	918/846	0.30	18	1.17 (0.97–1.40) (FEM)	0.10
	HWE (yes)	13	2909/3143	0.0003	67	0.93 (0.77–1.12) (REM)	0.44
aa versus bb	All	15	3183/3410	0.04	43	0.91 (0.73–1.14) (FEM)	0.40
	Asian	10	2265/2564	0.21	24	0.78 (0.61–1.01) (FEM)	0.06
	Caucasians	4	918/846	0.26	25	1.64 (0.98–2.73) (FEM)	0.06
	HWE (yes)	13	2909/3143	0.06	41	0.88 (0.70–1.11) (FEM)	0.28
aa + ab versus bb	All	15	3183/3410	0.002	60	0.91 (0.75–1.09) (REM)	0.30
	Asian	10	2265/2564	0.0004	61	0.82 (0.65–1.04) (REM)	0.11
	Caucasians	4	918/846	0.58	0	1.13 (0.91–1.40) (FEM)	0.26
	HWE (yes)	13	2909/3143	0.0007	65	0.89 (0.72–1.10) (REM)	0.30
aa versus bb + ab	All	15	3183/3410	0.21	22	1.01 (0.81–1.25) (FEM)	0.96
	Asian	10	2265/2564	0.49	0	0.90 (0.70–1.15) (FEM)	0.39
	Caucasians	4	918/846	0.28	21	1.60 (0.97–2.65) (FEM)	0.07
	HWE (yes)	13	2909/3143	0.30	14	0.98 (0.78–1.23) (FEM)	0.88

OR: odds ratio; CI: confidence interval.