Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice

Figure 2

Glomerular mesangiolysis in STZ eNOS −/− mice at 22 weeks after low-dose STZ injections. (a) Mesangiolysis is accompanied by afferent arteriole injury (arrow). (b and c) Prominent mesangiolysis (arrows) is observed in subpopulation of glomeruli, indicating heterogeneity of glomerular injury in this model. Note adjacent glomeruli exhibit mild glomerular lesion.

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(b)

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