Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular Disease

Table 2

Biochemical characteristics of the overall sample categorized according to glucose tolerance status.

Total = 939 individuals
Parameter	NGT; 𝑛=473 (50.4%)	Pre-DM; 𝑛=250 (26.6%)	T2DM; 𝑛=216 (23%)
FPG (mg/dL)
Mean ± SD	89.6±6.4	107±5.9^∗	158.1±68.1^∗†
Median [IQR]	90 [86–95]	105 [102–111]	135 [111–181]
HbA1c (%)
Mean ± SD	4.0±0.5	4.2±0.8^∗	5.9±2.1^∗†
Median [IQR]	3.9 [3.7–4.2]	4.1 [3.9–4.5]	5.2 [4.4–7.2]
HDL-C (mg/dL)
Mean ± SD	40.8±12.7	39±10.3	37.4±10.2^∗
Median [IQR]	39.2 [31.6–48.5]	37.1 [31.4–46]	35.9 [30.5–42.4]
Triglycerides (mg/dL)	184.1±117.2	222.3±154.8^∗	231.8±301.2^∗
Median [IQR]	159 [109–219]	182 [129–266]	191 [127–264]
Fibrinogen (mg/dL)
Mean ± SD	369.8±69.1	372±69.8	385.9±77.8^∗
Median [IQR]	365 [322–408]	370 [323–418]	377 [330–438]
hs-CRP (mg/L)
Mean ± SD	0.4±0.5	0.4±0.7	0.5±0.6^∗
Median [IQR]	0.3 [0.1–0.4]	0.2 [0.1–0.5]	0.3 [0.1–0.6]

Data are means ± standard deviation, median [interquartile range] and percentages; *P value ≤ 0.05 versus NGT; ^†P value ≤ 0.05 versus pre-DM; NGT: normal glucose tolerance; preDM: pre-diabetes mellitus; T2DM: type 2 diabetes mellitus; FPG: fasting plasma glucose; HbA1c: glycosylated hemoglobin; HDL-C: high-density lipoprotein colesterol; hs-CRP: high sensitivity C-reactive protein.