Histone Lysine Methylation in Diabetic Nephropathy

Table 1

Histone lysine methylations and HMTs/HDMs in DN.

Lysine	State	HMTs	HDMs	Target renal loci	Effects in DN	References
H3K4	me1; me2; me3	SET7/9; MLL1-4; MLL1-4	LSD1; LSD1	RMCs, ECs, and mice glomeruli; RMCs; RMCs	Upregulate profibrotic gene and stimulate NF-κB activated inflammatory genes	Sun et al. [43]; El-Osta et al. [33]; Reddy et al. [44]
H3K36	me3			Mice glomeruli	Stimulate profibrotic and proinflammatory genes expression	Reddy et al. [44]
H3K79		DOT1/DOT1L		Kidney collecting ducts	Develop polyuria	Wu et al. [45]
H3K9	me2	SUV39H1/2; G9a	LSD1	RMCs, monocyte/lymphocyte, and mice glomeruli	Repress inflammatory/profibrotic gene expression	Sun et al. [43]; Villeneuve et al. [46]; Reddy et al. [44]
	me3	SUV39H1		Human/mice VSMCs, RMCs, and mice glomeruli
H3K27	me3	EZH2	KDM6A	Mice glomeruli	Repress profibrotic genes expression	Reddy et al. [44]; Komers et al. [47]
H4K20	me1; me2; me3	SET8; SUV4-20H1/2; SUV4-20H1/2			Repress SOD expression	Zhong and Kowluru [29]