Table 1: The mean retinal thickness and mean area of stained GFAP in each group. 31 wDM: 31-week-old SDT rats; 33 wNDM: 33-week-old normal SD rats; NDM: normal SD rats older than 50 weeks; DM: untreated SD rats older than 50 weeks; rani (0.1): ranirestat-treated SDT rats (0.1 mg/kg/day); rani (1.0): ranirestat-treated SDT rats (1.0 mg/kg/day); rani (10): ranirestat-treated SDT rats (10 mg/kg/day); epa (100): epalrestat-treated SDT rats (100 mg/kg/day).

31 wDM33 wNDMNDMDMrani (0.1)rani (1.0)rani (10)epa (100)

Mean retinal thickness (μm)

value0.22
(compared with DM)
0.021
(compared with 33 wNDM)
0.023
(compared with NDM)
0.0076
(compared with DM)
0.017
(compared with DM)
0.0052
(compared with DM)
0.016
(compared with DM)
0.057
(compared with DM)

Mean area of stained
GFAP (µm2)

value0.0055
(compared with DM)
0.24
(compared with 33 wNDM)
0.0055
(compared with NDM)
0.0044
(compared with DM)
0.13
(compared with DM)
0.0052
(compared with DM)
0.028
(compared with DM)
0.11
(compared with DM)