Glyoxylate, a New Marker Metabolite of Type 2 Diabetes

Table 2

Comparison of db/db^−/− and wild-type mice for plasma and tissue levels of glyoxylate and metabolites involved in glyoxylate synthesis or degradation (n.s.: not significant and FC: fold-change db/db^−/− relative to wild-type).

Metabolite	Plasma		Liver		Quadriceps muscle
	FC	P value	FC	P value	FC	P value
Glucose	2.15		1.39		2.23
Glyoxylate	6.06		1.05	n.s.	0.67
Glycolate	1.13	n.s.	Not detected		Not detected
Glycine	0.81	n.s.	0.62		0.49
4-Hydroxyproline	0.26		0.26		0.14