Loss of Insulin Receptor in Osteoprogenitor Cells Impairs Structural Strength of Bone
Figure 2
OIRKO femurs are weaker and more slender. Loss of IR in osteoblasts caused the bone to be more slender (ratio of length to total cross-sectional area) relative to body weight (Length/Tt.AR per BW; (a), male; (b), female). Loss of IR in osteoblasts also caused a decrease in the structural strength of the femur in bending (peak force; (c), male; (d), female). Data is displayed as a scatter-plot, with mean and SEM indicated.
