Loss of Insulin Receptor in Osteoprogenitor Cells Impairs Structural Strength of Bone

Table 2

Metabolic phenotype of males (top) and females (bottom), comparing control (IR flox) and OIRKO mice.

	Units	IR flox (𝑛=6)	OIRKO (𝑛=9)	𝑃 value
Measurements (male)
Final body weight	g	24.7±2.2	19.3±2.0	<0.001
Fasting insulin	ng/mL	0.14±0.04	0.26±0.22	0.24
Fasting blood glucose	mg/dL	67.8±11.4	68.11±11.4	0.97
Insulin AUC	—	43.8±17.0	40.5±8.9	0.63
Glucose AUC	—	46,660 ± 10,660	43,450 ± 10,328	0.57
OC	ng/mL	109.6±9.7	99.5±38.7	0.54
RatLAPS	ng/mL	25.1±2.3	21.3±3.8	0.05
Measurements (female)
Final body weight	g	23.1±2.6	17.6±2.4	0.001
Fasting blood glucose	mg/dL	52.7±7.6	52.6±11.6	0.98
Glucose AUC	—	27,781 ± 3985	30,695 ± 5300	0.27
OC	ng/mL	120.7±38.1	92.5±35.0	0.16
RatLAPS	ng/mL	25.5±5.1	23.8±7.6^a	0.64

Abbreviations: AUC: Area under the curve; OC: osteocalcin; RatLAPS; a marker of bone resorption. ^a𝑛=8 for this measurement. Significant differences are highlighted in bold font.