Characterization of Diabetic Neuropathy in the Zucker Diabetic Sprague-Dawley Rat: A New Animal Model for Type 2 Diabetes

Figure 3

Thermal nociception, intraepidermal nerve fiber, and Langerhans cell density in age-matched Sprague Dawley and ZDSD rats. Thermal nociception (a), intraepidermal nerve fiber (b), and Langerhans cell (c) density were examined as described in the Methods section in Sprague Dawley (SD) and ZDSD rats. Inserts are representative images of skin from foot pads from Sprague-Dawley (left) and ZDSD (right) rats. The white arrows point out nerve fibers and the red arrows point out the Langerhans cell. The number of rats in each group was 10 and 9, respectively. Data are presented as the mean ± S.E.M. for thermal nociception in sec, intraepidermal nerve fiber as profiles per mm, and Langerhans cell as number of cells per mm. compared to Sprague Dawley rats.