Altered Expression Profile of Renal 𝜶_1D-Adrenergic Receptor in Diabetes and Its Modulation by PPAR Agonists

Table 1

Alpha-adrenergic receptor gene expression in the kidney cortex of Zucker lean (ZL), untreated Zucker diabetic fatty (ZD), and fenofibrate-treated diabetic fatty (F-ZD) rats.

Accession number	Gene name	mRNA expression ZL	ZD versus ZL		F-ZD versus ZD
			Fold change	𝑃 value	Fold change	𝑃 value
NM_017191	𝛼1A-adrenergic receptor (𝛼1A-AR)	10.4 ± 2.9	NA	NA	NA	NA
NM_016991	𝛼1B-adrenergic receptor (𝛼1B-AR)	1372.2 ± 101.8	1.49	NS	1.26	NS
NM_024483	𝛼1D-adrenergic receptor (𝛼1D-AR)	273.3 ± 142.9	6.53	<0.001	−2.75	<0.001
NM_012739	𝛼2A-adrenergic receptor (𝛼2A-AR)	53.2 ± 15.2	−1.09	NS	1.02	NS
NM_138505	𝛼2B-adrenergic receptor (𝛼2B-AR)	116.8 ± 22.8	−1.18	NS	1.05	NS
NM_138506	α 2C-adrenergic receptor (α 2C-AR)	33.1 ± 7.9	1.19	NS	1.07	NS

Data are shown in two ways: mRNA expression level presenting the relative abundance of different alpha-adrenergic receptor subtypes in normal rat kidney cortex and fold change showing the differential expression of these genes among ZL, ZD, and F-ZD groups. There is significant (𝑃<0.001) upregulation in renal expression of 𝛼_1D-AR gene in the ZD animals, which is markedly prevented by fenofibrate treatment (𝑃<0.001). NA: not analyzed due to its low expression level in ZL, ZD, and F-ZD animals; NS: not significant.