Evaluation of Hypoglycemic Efficacy of Tangningtongluo Formula, a Traditional Chinese Miao Medicine, in Two Rodent Animal Models

Figure 5

OGTT in db/db mice. TNTL reduced the blood glucose (a) after oral high dose of glucose and decreased the area under the glucose response curve (b). As expected, metformin significantly lowered the AUC in db/db mice compared with diabetic model. Furthermore, TNTL (TNTL-h, m, l = 3.6 g, 1.8 and 0.9 g/kg b.w., resp.) administration significantly lowered the AUC in db/db mice, compared with metformin. Control: C57BL, DM: db/db mice with untreated, Met: db/db mice treated with metformin, and TNTL-h, m, l: db/db mice treated with 3.6 g, 1.8 and 0.9 g/kg b.w., respectively. compared with DM group. compared with metformin group.

(a)

(b)