Evaluation of Hypoglycemic Efficacy of Tangningtongluo Formula, a Traditional Chinese Miao Medicine, in Two Rodent Animal Models

Figure 9

Retinal imaging by OCT and FA in db/db diabetic mice. (A)–(F) Results of examination of the fundus by fluorescein angiography (FA), (a)–(f) Results of retinal imaging by optical coherence tomography (OCT). The OCT result shows the optic nerve fiber layer of db/db mice thinned (b), compared with the nondiabetic group (a). The thinning of optic nerve fiber layer was mildly reversed by the TNTL treatment ((d), (e), and (f) at the dose of 3.6 g, 1.8 and 0.9 g/kg b.w., resp.). There is no alleviation in the Met treatment mice (c) for the optic nerve fiber layer thickness. FA shows that there are numerous vascular calibers (pathological neovascularization) in the db/db mice fundus (B). The TNTL treatment ((D), (E), and (F) at the dose of 3.6 g, 1.8 and 0.9 g/kg b.w., resp.) can significantly reduce the density of vascular calibers in fundus oculi; nevertheless, the positive group (C) shows no significant alleviation.