Comparative MicroRNA Expression Profiles of Cynomolgus Monkeys, Rat, and Human Reveal that miR-182 Is Involved in T2D Pathogenic Processes

Figure 1

The general expression tendencies of the 24 specific miRNAs in All comparison, intact comparison, and HFD comparisongroups. The comparisons were carried out following the criteria where T2D individuals were compared with no-T2D individuals. All comparisons were carried out in all the monkeys without considering the diet conditions, while intact comparison was only in intact monkeys and HFD comparison was in HFD monkeys. (a) The Venn diagram represents the numbers of differential expressed miRNAs in All comparison (blue), intact comparison (green), and HFD comparison (red) groups. (b) The 7 specific miRNAs in the All comparison groups. All the miRNAs are in the same expression tendencies except miR-9. The positive values of the fold change mean that the miRNAs are upregulated in the T2D samples, whereas the negative values mean the downregulated expression. (c) The specific 7 miRNAs uniquely existed in the intact comparison group. Without miR-486-3p, miR-499a, and miR-99a in inconsistent expression between intact and HFD groups, others are in the same expression tendencies. (d) The 10 specific miRNAs uniquely existed in the HFD group. All of the miRNAs, except miR-196a and miR-96, are in inconsistent expression tendencies between the intact and HFD induced groups. Statistically significant differences are tested at significance. The significance in -test was labeled in black color, whilst that in ANOVA test was in red color (, ).

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