Comparative MicroRNA Expression Profiles of Cynomolgus Monkeys, Rat, and Human Reveal that miR-182 Is Involved in T2D Pathogenic Processes

Table 2

The details of the differential expressed miR-182 in the T2D individuals.

Species and tissue	Fold change (T2D/normal)	value	Reference or accession ID
Human blood (lean)		0.2651	GSE27645
Human blood (obese)		0.7116	GSE27645
Human blood		0.0400	[6]
Rat blood		0.0050	[6]
Rat adipose		0.0010	[6]
Rat pancreas		0.0020	[6]
Rat skeletal muscle		0.0230	[6]
Rat liver		0.0110	[6]
Cynomolgus blood (All comparison)		0.0224	—
Cynomolgus blood (intact comparison)		0.0047	—
Cynomolgus blood (HFD comparison)		0.1645	—
Valid target genes of miR-182	ADCY6, AKT1, ARRDC3, ATOH1, BAX, BCL2, BCL2L11, BDNF, BHLHB5, BRCA1, CASP2, CCL27, CCND1, CCND2, CD38, CDC42, CDKN1A, CLOCK, COX8A, CREB1, CTTN, CYLD, DICER1, DNTT, DOK4, E2F3, EGFR, EGR1, EIF2C1, EIF2C2, EIF2C3, ENPP3, EP300, ERBB2, EVI1, FBXW7, FOXF2, FOXO1, FOXO3, FRAP1, HBEGF, HMGA2, IL17A, IL17F, IL2, IRAK2, JAK2, KIT, MITF, MOCOS, MOS, MTSS1, MYB, MYC, MYCN, MITF, NAMPT, NEUROD4, NFIB, NRIP1, PAK1, PAK3, PCNA, PDCD4, PFN1, PNLIP, PRB1, PRMT5, PTEN, RAC1, RARG, RDX, RECK, RELA, RGS17, RNASEN, ROS1, SAG, SIRT1, SLC12A2, SLC1A1, SLC7A5, SMAD4, SNAI2, SOX6, SSSCA1, TNF, TP53, TSC22D3, TBX1, ZEB1, ZEB2, ZNF828