Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach

Table 1

Dysfunction pathways between human T2D islet cells and normal islet cells.

Pathway	Count	value
Eicosanoid synthesis	3	0.0016
MAPK signaling pathway	7	0.0029
IL-6 signaling pathway	4	0.005
Integrated Pancreatic Cancer Pathway	7	0.0055
Mitochondrial LC-Fatty Acid Beta-Oxidation	2	0.0152
Complement and Coagulation Cascades	3	0.0205
Focal adhesion	6	0.021
Selenium Pathway	4	0.0316
IL-7 signaling pathway	2	0.0354
TGF-beta signaling pathway	3	0.0362
IL-1 signaling pathway	3	0.0377
Fatty Acid Biosynthesis	2	0.0436
Tryptophan metabolism	3	0.0441
Inflammatory Response Pathway	2	0.0464
Prostaglandin Synthesis and Regulation	2	0.0494