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Journal of Diabetes Research
Volume 2014, Article ID 785948, 9 pages
http://dx.doi.org/10.1155/2014/785948
Review Article

Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation

1Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi’an Jiaotong University, Xi’an 710061, China
2Department of Endocrinology, First Affiliated Hospital, Medical College, Xi’an Jiaotong University, Xi’an 710061, China

Received 13 August 2014; Revised 2 October 2014; Accepted 7 October 2014; Published 20 October 2014

Academic Editor: Subrata Chakrabarti

Copyright © 2014 Haitao Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates (NHPs) represent the suitable models of DMs to better evaluate the effectiveness of islet transplantation, to assess new strategies for controlling blood glucose (BG), relieving immune rejection, or prolonging islet survival, and eventually to translate the preclinical data into tangible clinical practice. This review introduces some NHP models of DM, clarifies why and how the models should be used, and elucidates the usefulness and limitations of the models in islet transplantation.