Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats
Figure 5
Decline in dendritic spine density in the frontal cortex and hippocampus of rats at 4 months after STZ injection. (a) Representative images of the dendritic spine of the pyramidal neurons in cortical layers II/III. (b) Representative images of the dendritic spine of the pyramidal neurons in the CA1 region of the hippocampus. (c) Dendritic spine density in the frontal cortex and hippocampus was measured (see Materials and Methods for procedure details). , significant difference compared with the age-matched control rats; . (d) Representative images of synaptophysin expression in the frontal cortex using western blot analysis. (e) Representative images of synaptophysin expression in the hippocampus using western blot analysis. (f) Relative expression of synaptophysin in the frontal cortex and hippocampus was determined. , significant difference compared with the age-matched control group; .
