The Role of MIF in Type 1 and Type 2 Diabetes Mellitus

Figure 2

MIF involvement in T1DM development. (1) MIF promotes pancreatic β cell apoptosis. (2) MIF promotes the production of inflammatory cytokines such as IL-1β, TNF-α, and IL-12. (3) MIF favors autoantigen presentation. (4) MIF promotes the activation of an inflammatory response, leading to insulitis.