Review Article
The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
Table 1
Characteristics of all studies assessing the relationship between VEGF and diabetic retinopathy (DR versus DWR).
| First author | Year | Country/racial decent | Study design | Casesa (DR) | Controlsa (DWR) | | Cases | | | Controls | | HWE | 11b | 12b | 22b | 11b | 12b | 22b | control population |
| −634 G>C (rs2010963) | Awata [17] | 2005 | Japan (Asian) | Hospital based controls | 175 | 203 | 46 | 91 | 38 | 75 | 95 | 30 | 0.99 | Globočnik Petrovič [18] | 2008 | Slovene (Caucasian) | Hospital based controls | 206 | 143 | 79 | 103 | 24 | 61 | 67 | 15 | 0.58 | Uthra [19] | 2008 | India (Asian) | Population based controls | 131 | 82 | 60 | 51 | 9 | 44 | 29 | 6 | 0.69 | Nakamura [20] | 2009 | Japan (Asian) | Hospital based controls | 177 | 292 | 63 | 79 | 34 | 84 | 146 | 59 | 0.75 | Chun [21] | 2010 | Korea (Asian) | Hospital based controls | 253 | 134 | 85 | 125 | 43 | 43 | 69 | 22 | 0.51 | Yang [22] | 2011 | China (Asian) | Hospital based controls | 129 | 139 | 36 | 74 | 19 | 39 | 72 | 26 | 0.47 | Bleda [23] | 2012 | Spain (Caucasian) | Hospital based controls | 14 | 26 | 7 | 5 | 2 | 10 | 11 | 5 | 0.53 |
| –2578 C/A (rs699947) | Awata [17] | 2005 | Japan (Asian) | Hospital based controls | 175 | 203 | 95 | 70 | 10 | 93 | 91 | 19 | 0.62 | Abhary [24] | 2009 | Australia (Caucasian) | Hospital based controls | 139 | 187 | 31 | 74 | 31 | 45 | 91 | 45 | 0.94 | Nakamura [20] | 2009 | Japan (Asian) | Hospital based controls | 177 | 292 | 85 | 70 | 22 | 163 | 107 | 22 | 0.44 | Chun [21] | 2010 | Korea (Asian) | Hospital based controls | 253 | 134 | 123 | 115 | 15 | 92 | 36 | 6 | 0.31 | Yang [22] | 2011 | China (Asian) | Hospital based controls | 129 | 139 | 66 | 47 | 16 | 82 | 51 | 5 | 0.38 | Bleda [23] | 2012 | Spain (Caucasian) | Hospital based controls | 14 | 26 | 0 | 12 | 2 | 8 | 10 | 8 | 0.23 |
| +936 C/T (rs3025039) | Awata [25] | 2002 | Japan (Asian) | Hospital based controls | 150 | 118 | 93 | 47 | 10 | 85 | 31 | 2 | 0.66 | Uthra [19] | 2008 | India (Asian) | Population based controls | 131 | 82 | 111 | 19 | 0 | 65 | 17 | 0 | 0.29 | Kim [26] | 2009 | Korea (Asian) | Population based controls | 121 | 277 | 55 | 63 | 3 | 226 | 51 | 0 | 0.09 | Yang [22] | 2011 | China (Asian) | Hospital based controls | 129 | 139 | 83 | 42 | 3 | 89 | 47 | 3 | 0.25 |
| −460 T/C (rs833061) | Awata [25] | 2002 | Japan (Asian) | Hospital based controls | 150 | 118 | 79 | 58 | 13 | 52 | 57 | 9 | 0.21 | Suganthalakshmi [27] | 2006 | India (Asian) | Hospital based controls | 120 | 90 | 36 | 81 | 3 | 61 | 29 | 0 | 0.06 | Yang [22] | 2011 | China (Asian) | Hospital based controls | 129 | 139 | 65 | 46 | 16 | 81 | 52 | 5 | 0.33 |
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DR: diabetic retinopathy; DWR: diabetic without retinopathy; HWE: Hardy-Weinberg equilibrium.
aSample size.
b11: wild-type homozygote; 12: heterozygote; 22: variant homozygote.
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