Journal of Diabetes Research / 2014 / Article / Tab 1

Review Article

The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Table 1

Characteristics of all studies assessing the relationship between VEGF and diabetic retinopathy (DR versus DWR).

First authorYearCountry/racial decentStudy designCasesa (DR)Controlsa (DWR)CasesControlsHWE
11b12b22b11b12b22b control population

−634 G>C (rs2010963)
Awata [17]2005Japan (Asian)Hospital based controls1752034691387595300.99
Globočnik Petrovič [18]2008Slovene (Caucasian)Hospital based controls20614379103246167150.58
Uthra [19]2008India (Asian)Population based controls1318260519442960.69
Nakamura [20]2009Japan (Asian)Hospital based controls17729263793484146590.75
Chun [21]2010Korea (Asian)Hospital based controls25313485125434369220.51
Yang [22]2011China (Asian)Hospital based controls1291393674193972260.47
Bleda [23]2012Spain (Caucasian)Hospital based controls1426752101150.53

–2578 C/A (rs699947)
Awata [17]2005Japan (Asian)Hospital based controls1752039570109391190.62
Abhary [24]2009Australia (Caucasian)Hospital based controls1391873174314591450.94
Nakamura [20]2009Japan (Asian)Hospital based controls177292857022163107220.44
Chun [21]2010Korea (Asian)Hospital based controls25313412311515923660.31
Yang [22]2011China (Asian)Hospital based controls129139664716825150.38
Bleda [23]2012Spain (Caucasian)Hospital based controls1426012281080.23

+936 C/T (rs3025039)
Awata [25]2002Japan (Asian)Hospital based controls150118934710853120.66
Uthra [19]2008India (Asian)Population based controls13182111190651700.29
Kim [26]2009Korea (Asian)Population based controls121277556332265100.09
Yang [22]2011China (Asian)Hospital based controls12913983423894730.25

−460 T/C (rs833061)
Awata [25]2002Japan (Asian)Hospital based controls150118795813525790.21
Suganthalakshmi [27]2006India (Asian)Hospital based controls1209036813612900.06
Yang [22]2011China (Asian)Hospital based controls129139654616815250.33

DR: diabetic retinopathy; DWR: diabetic without retinopathy; HWE: Hardy-Weinberg equilibrium.
aSample size.
b11: wild-type homozygote; 12: heterozygote; 22: variant homozygote.

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