JNK3 Is Required for the Cytoprotective Effect of Exendin 4
Figure 1
The effect of exendin 4 on the JNK3 content. JNK3 abundance in (a) isolated human islets (from three different donors) cultured with 50 nM exendin 4 for the indicated times or (b) with different exendin 4 concentrations for 4 hrs. (c) INS-1E cells cultured with 50 nM exendin 4 for the indicated times. For western blotting experiments, protein extracts (50 μg) were loaded into a polyacrylamide gel electrophoresis. Immunoblotting was achieved using the anti-JNK3 and anti-β-actin antibodies. The data is one representative experiment out of three.
