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Journal of Diabetes Research
Volume 2014 (2014), Article ID 835392, 6 pages
http://dx.doi.org/10.1155/2014/835392
Research Article

Relationship between Autonomic Nervous System Function and Continuous Interstitial Glucose Measurement in Patients with Type 2 Diabetes

1First Department of Propaedeutic Internal Medicine, Athens University Medical School, Laiko General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece
2Department of Cardiology, Laiko General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece

Received 1 July 2014; Accepted 5 July 2014; Published 3 August 2014

Academic Editor: Nikolaos Papanas

Copyright © 2014 Stavroula Kalopita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Ziegler, “Diabetic cardiovascular autonomic neuropathy: Prognosis, diagnosis and treatment,” Diabetes/Metabolism Reviews, vol. 10, no. 4, pp. 339–383, 1994. View at Google Scholar · View at Scopus
  2. J. P. Singh, M. G. Larson, C. J. O'Donnell et al., “Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study),” American Journal of Cardiology, vol. 86, no. 3, pp. 309–312, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. Pfeifer, C. R. Weinberg, D. L. Cook et al., “Autonomic neural dysfunction in recently diagnosed diabetic subjects,” Diabetes Care, vol. 7, no. 5, pp. 447–453, 1984. View at Publisher · View at Google Scholar · View at Scopus
  4. A. I. Vinik, R. E. Maser, and D. Ziegler, “Autonomic imbalance: prophet of doom or scope for hope?” Diabetic Medicine, vol. 28, no. 6, pp. 643–651, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. R. E. Maser, B. D. Mitchell, A. I. Vinik, and R. Freeman, “The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes a meta-analysis,” Diabetes Care, vol. 26, no. 6, pp. 1895–1901, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. A. I. Vinik, R. E. Maser, B. D. Mitchell, and R. Freeman, “Diabetic autonomic neuropathy,” Diabetes Care, vol. 26, no. 5, pp. 1553–1579, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, “Heart rate variability: standards of measurement, physiological interpretation and clinical use,” Circulation, vol. 93, no. 5, pp. 1043–1065, 1996. View at Google Scholar
  8. R. Pop-Busui, “Cardiac autonomic neuropathy in diabetes: a clinical perspective,” Diabetes Care, vol. 33, no. 2, pp. 434–441, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Monnier, E. Mas, C. Ginet et al., “Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes,” The Journal of the American Medical Association, vol. 295, no. 14, pp. 1681–1687, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. J. S. Krinsley, “Glycemic variability: a strong independent predictor of mortality in critically ill patients,” Critical Care Medicine, vol. 36, no. 11, pp. 3008–3013, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. E. S. Kilpatrick, A. S. Rigby, and S. L. Atkin, “For debate: glucose variability and diabetes complication risk: we need to know the answer,” Diabetic Medicine, vol. 27, no. 8, pp. 868–871, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Fleischer, “Diabetic autonomic imbalance and glycemic variability,” Journal of Diabetes Science and Technology, vol. 6, no. 5, pp. 1207–1215, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Esposito, F. Nappo, R. Marfella et al., “Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress,” Circulation, vol. 106, no. 16, pp. 2067–2072, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. G. McGarraugh, “The chemistry of commercial continuous glucose monitors,” Diabetes Technology and Therapeutics, vol. 11, supplement 1, pp. S17–S24, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Rodbard, “New and improved methods to characterize glycemic variability using continuous glucose monitoring,” Diabetes Technology and Therapeutics, vol. 11, no. 9, pp. 551–565, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Google Scholar · View at Scopus
  17. J. R. Williams, “The Declaration of Helsinki and public health,” Bulletin of the World Health Organization, vol. 86, no. 8, pp. 650–652, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. D. C. Klonoff, “Continuous glucose monitoring: roadmap for 21st century diabetes therapy,” Diabetes Care, vol. 28, no. 5, pp. 1231–1239, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. F. J. Service, G. D. Molnar, J. W. Rosevear, E. Ackerman, L. C. Gatewood, and W. F. Taylor, “Mean amplitude of glycemic excursions, a measure of diabetic instability,” Diabetes, vol. 19, no. 9, pp. 644–655, 1970. View at Google Scholar · View at Scopus
  20. J. Schlichtkrull, O. Munck, and M. Jersild, “The M-value, an index of blood sugar control in diabetics,” Acta Medica Scandinavica, vol. 177, pp. 95–102, 1965. View at Google Scholar · View at Scopus
  21. A. Di Flaviani, F. Picconi, P. Di Stefano et al., “Impact of glycemic and blood pressure variability on surrogate measures of cardiovascular outcomes in type 2 diabetic patients,” Diabetes Care, vol. 34, no. 7, pp. 1605–1609, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. M. Wawryk, D. J. Bates, and J. J. Couper, “Power spectral analysis of heart rate variability in children and adolescents with IDDM,” Diabetes Care, vol. 20, no. 9, pp. 1416–1421, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. P. K. Stein, J. I. Barzilay, P. P. Domitrovich et al., “The relationship of heart rate and heart rate variability to non-diabetic fasting glucose levels and the metabolic syndrome: the Cardiovascular Health Study,” Diabetic Medicine, vol. 24, no. 8, pp. 855–863, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. E. B. Schroeder, L. E. Chambless, D. Liao et al., “Diabetes, glucose, insulin, and heart rate variability: The Atherosclerosis Risk in Communities (ARIC) study,” Diabetes Care, vol. 28, no. 3, pp. 668–674, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. The Diabetes Control and Complications Trial Researh Group, “The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial,” Diabetes, vol. 44, no. 8, pp. 968–983, 1995. View at Publisher · View at Google Scholar
  26. E. S. Kilpatrick, A. S. Rigby, and S. L. Atkin, “The effect of glucose variability on the risk of microvascular complications in type 1 diabetes,” Diabetes Care, vol. 29, no. 7, pp. 1486–1490, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. E. S. Kilpatrick, A. S. Rigby, and S. L. Atkin, “A1C variability and the risk of microvascular complications in type 1 diabetes: data from the diabetes control and complications trial,” Diabetes Care, vol. 31, no. 11, pp. 2198–2202, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J. W. Rowe, J. B. Young, K. L. Minaker, A. L. Stevens, J. Pallotta, and L. Landsberg, “Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man,” Diabetes, vol. 30, no. 3, pp. 219–225, 1981. View at Publisher · View at Google Scholar · View at Scopus
  29. N. S. Schwartz, W. E. Clutter, S. D. Shah, and P. E. Cryer, “Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms,” The Journal of Clinical Investigation, vol. 79, no. 3, pp. 777–781, 1987. View at Google Scholar · View at Scopus
  30. B. Ohlsson, O. Melander, O. Thorsson, R. Olsson, O. Ekberg, and G. Sundkvist, “Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis,” Diabetologia, vol. 49, no. 9, pp. 2010–2014, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. S. E. Siegelaar, F. Holleman, J. B. L. Hoekstra, and J. H. DeVries, “Glucose variability; does it matter?” Endocrine Reviews, vol. 31, no. 2, pp. 171–182, 2010. View at Publisher · View at Google Scholar · View at Scopus