ACE Insertion/Deletion Polymorphism and Diabetic Nephropathy: Clinical Implications of Genetic Information

Table 2

Studies examining the association of the ACE I/D polymorphism and response to antiproteinuric (renoprotective) effect of ARB therapy.

Authors; (Year)	Ethnicity	Disease and patient number	Study durations; (month)	Therapy; drug	Effects on proteinuria or progression	Reference
Andersen et al. (2002)	Caucasian	Type 1 DM (54)	4	Losartan	No differences in; reduction of proteinuria	[50]
Andersen et al. (2003)	Caucasian	Type 1 DM (54)	36	Losartan	No differences in; reduction of proteinuria	[51]
Haneda et al. (2004)	Asian; (Japanese)	Type 2 DM (127)	3	Candesartan	No differences in; reduction of proteinuria	[52]
Parving et al. (2008)	Mixed	Type 2 DM (1435)	40.8	Losartan	DD genotype more risk; reduction reaching; ESRD	[53]
Cheema et al. (2013)	Asian; (Indian)	Type 2 DM (320)	36	ARBs	DD genotype associated; with better; renoprotective response	[49]

ARB: angiotensin receptor blocker; ACE I/D polymorphism: angiotensin converting enzyme insertion/deletion polymorphism.