Research Article
Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men
Table 1
General clinical characteristics of the study participants.
| | General characteristics | Control () | T2DM () | T2DM + CHD () |
| | Age (years) | 60.23 ± 10.41 | 63.72 ± 9.66∗ | 63.88 ± 10.61∗∗ | | Sex (M/F) | 680/704 | 632/616 | 576/576 | | BMI (kg/m2) | 22.6 ± 2.9 | 25.4 ± 2.8∗ | 26.8 ± 2.4∗∗ | | Nondrinker (%) | 80.6 | 78.3 | 65.4 | | Current drinker (%) | 17.6 | 20.6 | 32.5∗∗ | | Former drinker (%) | 2.2 | 2.3 | 2.3 | | Nonsmoker (%) | 63.1 | 55.3∗ | 53.0∗∗ | | Current smoker (%) | 32.8 | 40.3∗ | 42.8∗∗ | | Former smoker (%) | 4.1 | 4.4 | 4.2 | | FPG (mmol/L) | 4.62 ± 1.2 | 9.40 ± 2.4∗ | 10.01 ± 2.4∗∗ | | HbA1c (mmol/L) | 4.43 ± 1.1 | 8.12 ± 1.3∗ | 9.46 ± 1.5∗∗ | | TC (mmol/L) | 4.47 ± 0.92 | 5.24 ± 1.24 | 5.72 ± 1.00 | | TG (mmol/L) | 1.54 ± 0.72 | 2.84 ± 1.25∗ | 3.20 ± 1.43∗∗ | | HDL-C (mmol/L) | 1.37 ± 0.21 | 1.24 ± 0.22∗ | 1.11 ± 0.19∗∗ | | LDL-C (mmol/L) | 2.83 ± 0.75 | 2.92 ± 0.75 | 2.85 ± 0.77 | | hs-CRP | 0.16 ± 0.08 | 1.98 ± 0.42∗ | 5.08 ± 1.03∗∗ |
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∗ comparison between controls and T2DM, ∗∗ comparison between controls and T2DM + CHD. BMI, body mass index; FPG, fasting plasma glucose; HbA1c, hemoglobin A1c; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; T2DM, type 2 diabetes mellitus; CHD, coronary heart disease.
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